Efficacy and Safety of Ketogenic Diet as Adjunctive Treatment in Adults With Refractory Epilepsy - Full Text View. The goal of the present open label study is to obtain pilot data to evaluate the efficacy and safety of KD in adults with intractable epilepsy. Investigators will evaluate the effect of KD on seizure frequency and on adverse events. Investigators will also evaluate serum levels of the ketone body, . The data from the present study will be used to design a large randomized study. Laboratory evaluations will include complete blood count (CBC), serum electrolytes, including calcium, phosphate and magnesium, renal and liver functions, including total protein and albumin, uric acid, fasting serum lipid profile, glucose and b- hydroxybutyrate (BOH) levels, serum carnitine level, serum a. They will be obtained twice at baseline a month apart and monthly during KD treatment. Primary outcome measures will include average monthly seizure frequency and adverse events. Secondary outcome measures will include treatment compliance, quality of life questionnaire (QOLIE- 3. P) scores, and Epworth Sleepiness Scale scores. Simple partial seizures (eight cases total) were higher with soy-based formula for both genders but only reached statistical significance when combining the data. Why do women with epilepsy often have more reproductive disorders than women without seizures? The ketogenic diet is one of the oldest treatments for epilepsy. It is intended to maintain the starvation or fasting metabolism over a long period of time. When the body is in a fasting state, it creates ketones, a by-product of fat-burning metabolism. It has long been recognized that seizures. Simple partial seizures. Symptoms may include involuntary twitching of the muscles or arms and legs; changes in vision; vertigo. The person may have an aura or an unusual feeling before the seizure starts. There are many causes of seizures. The factors that lead to a seizure are often complex and it may not be possible to determine what causes a particular seizure, what causes it to happen at a particular time, or how often seizures occur.
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